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Design of 3D Printing Thermo-Sensored Medical Gear in Detecting COVID-19 Symptoms
Shortly after the outbreak of the COVID-19 pandemic, there was a need to provide protective equipment to the medical facilities whose supplies were threatened to be depleted. Just like many countries in Europe, Montenegro responded to the need for…
Position: 16456 (19 views)
Design of a Multiepitope-Based Peptide Vaccine against the E Protein of Human COVID-19: An Immunoinformatics Approach
Background. A new endemic disease has spread across Wuhan City, China, in December 2019. Within few weeks, the World Health Organization (WHO) announced a novel coronavirus designated as coronavirus disease 2019 (COVID-19). In late January 2020, WHO…
Position: 13616 (22 views)
Design of an epitope-based peptide vaccine against spike protein of human coronavirus: an in silico approach
Arafat Rahman Oany,1 Abdullah-Al Emran,1,2 Tahmina Pervin Jyoti3 1Department of Biotechnology and Genetic Engineering, Life Science Faculty, Mawlana Bhashani Science and Technology University, Tangail, Bangladesh; 2Translational Research Institute,…
Position: 12639 (23 views)
Design of an epitope-based peptide vaccine against the SARS-CoV-2: a vaccine-informatics approach.
The recurrent and recent global outbreak of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has turned into a global concern which has infected more than 42 million people all over the globe, and this number is increasing in hours.…
Position: 15543 (20 views)
Design of Novel ETL Model to Analyse Corona Virus Data
INTRODUCTION:The corona disease was first recognized in 2019 in Wuhan, which is the capital of China’s Hubei-province,and from then it continued spreading and as a result declared as a pandemic by all nations. The COVID-19virus has different effects…
Position: 18807 (16 views)
Design of wide-spectrum inhibitors targeting coronavirus main proteases.
The genus Coronavirus contains about 25 species of coronaviruses (CoVs), which are important pathogens causing highly prevalent diseases and often severe or fatal in humans and animals. No licensed specific drugs are available to prevent their…
Position: 12639 (23 views)
Design, Synthesis and Antifungal Activity of Novel Benzofuran-Triazole Hybrids
A series of novel benzofuran-triazole hybrids was designed and synthesized by click chemistry, and their structures were characterized by HRMS, FTIR and NMR. The in vitro antifungal activity of target compounds was evaluated using the microdilution…
Position: 5526 (34 views)
Design, Synthesis and Biological Evaluation of Novel Bromophenol Derivatives Incorporating Indolin-2-One Moiety as Potential Anticancer Agents
A series of bromophenol derivatives containing indolin-2-one moiety were designed and evaluated that for their anticancer activities against A549, Bel7402, HepG2, HeLa and HCT116 cancer cell lines using MTT assay in vitro. Among them, seven compounds…
Position: 4363 (38 views)
Design, Synthesis and Biological Evaluation of Novel Phenylsulfonylurea Derivatives as PI3K/mTOR Dual Inhibitors
Five series of novel phenylsulfonylurea derivatives, 19a–d, 20a–d, 21a–d, 22a–d and 23a–d, bearing 4-phenylaminoquinoline scaffold were designed, synthesized and their IC50 values against four cancer cell lines (HepG-2,…
Position: 6331 (32 views)
Design, synthesis and biological evaluation of novel piperazine derivatives as CCR5 antagonists.
By using a fragment-assembly strategy and bioisosteric-replacement principle, a series of novel piperazine derivatives were designed, synthesized, and evaluated for their cellular target-effector fusion activities and in vitro antiviral activities…
Position: 7904 (29 views)