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2'-O methylation of the viral mRNA cap by West Nile virus evades ifit1-dependent and -independent mechanisms of host restriction in vivo.
Prior studies have shown that 2'-O methyltransferase activity of flaviviruses, coronaviruses, and poxviruses promotes viral evasion of Ifit1, an interferon-stimulated innate immune effector protein. Viruses lacking 2'-O methyltransferase activity…
Position: 5537 (38 views)
Reflections on Virtual Care for Chronic Conditions During the COVID-19 Pandemic.
Position: 12479 (26 views)
Genetic variation in the Staphylococcus aureus 8325 strain lineage revealed by whole-genome sequencing.
Staphylococcus aureus strains of the 8325 lineage, especially 8325-4 and derivatives lacking prophage, have been used extensively for decades of research. We report herein the results of our deep sequence analysis of strain 8325-4. Assignment of…
Position: 4657 (41 views)
A Parsimonious Description and Cross-Country Analysis of COVID-19 Epidemic Curves
In a given country, the cumulative death toll of the first wave of the COVID-19 epidemic follows a sigmoid curve as a function of time. In most cases, the curve is well described by the Gompertz function, which is characterized by two essential…
Position: 4923 (40 views)
The role of myeloid cell activation and arginine metabolism in the pathogenesis of virus-induced diseases
When an antiviral immune response is generated, a balance must be reached between two opposing pathways: the production of proinflammatory and cytotoxic effectors that drive a robust antiviral immune response to control the infection and regulators…
Position: 7561 (33 views)
Design, Synthesis and Biological Evaluation of Novel Primaquine-Cinnamic Acid Conjugates of the Amide and Acylsemicarbazide Type
In this paper design and synthesis of a scaffold comprising primaquine (PQ) motif and cinnamic acid derivatives (CADs) bound directly (compounds 3a–k) or via a spacer (compounds 7a–k) are reported. In the first series of compounds, PQ and various…
Position: 12479 (26 views)
Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.
Pneumonia may be caused by a wide range of pathogens and is considered the most common infectious cause of death in humans. Murine acute lung infection models mirror human pathologies in many aspects and contribute to our understanding of the disease…
Position: 506 (84 views)
Identify-Isolate-Inform: A Tool for Initial Detection and Management of Zika Virus Patients in the Emergency Department
First isolated in 1947 from a monkey in the Zika forest in Uganda, and from mosquitoes in the same forest the following year, Zika virus has gained international attention due to concerns for infection in pregnant women potentially causing fetal…
Position: 15144 (23 views)
Identify-Isolate-Inform: A Modified Tool for Initial Detection and Management of Middle East Respiratory Syndrome Patients in the Emergency Department
Middle East respiratory syndrome (MERS) is a novel infectious disease caused by a coronavirus(MERS-CoV) first reported in Saudi Arabia in September 2012. MERS later spread to other countriesin the Arabian Peninsula, followed by an outbreak in South…
Position: 12479 (26 views)
Identification of electrode respiring, hydrocarbonoclastic bacterial strain Stenotrophomonas maltophilia MK2 highlights the untapped potential for environmental bioremediation
Electrode respiring bacteria (ERB) possess a great potential for many biotechnological applications such as microbial electrochemical remediation systems (MERS) because of their exoelectrogenic capabilities to degrade xenobiotic pollutants. Very few…
Position: 5872 (37 views)