Clinical epidemiology of bocavirus, rhinovirus, two polyomaviruses and four coronaviruses in HIV-infected and HIV-uninfected South African children.

Clinical epidemiology of bocavirus, rhinovirus, two polyomaviruses and four coronaviruses in HIV-infected and HIV-uninfected South African children.

Marta C Nunes, Zachary Kuschner, Zelda Rabede, Richard Madimabe, Nadia van Niekerk, Jackie Moloi, Locadiah Kuwanda, John W Rossen, Keith P. Klugman, Peter V. Adrian, Shabir A Madhi

BACKGROUND:Advances in molecular diagnostics have implicated newly-discovered respiratory viruses in the pathogenesis of pneumonia. We aimed to determine the prevalence and clinical characteristics of human bocavirus (hBoV), human rhinovirus (hRV), polyomavirus-WU (WUPyV) and -KI (KIPyV) and human coronaviruses (CoV)-OC43, -NL63, -HKU1 and -229E among children hospitalized with lower respiratory tract infections (LRTI). METHODS:Multiplex real-time reverse-transcriptase polymerase chain reaction was undertaken on archived nasopharyngeal aspirates from HIV-infected and -uninfected children (

2014

DOI: 10.1371/journal.pone.0086448

PLoS ONE

Public Library of Science (PLoS)

Science, Medicine

EN