A Lung Transcriptomic Analysis for Exploring Host Response in COVID-19

A Lung Transcriptomic Analysis for Exploring Host Response in COVID-19

Utkarsh Raj, Uma Chaudhary, Somya Gupta, Aditya Saxena, Alok Bharadwaj, Nitin Wahi, Jitender Reddy Kalli, Shravya Gupta, Sparsh Kumar

Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2) rose without precedent for Wuhan,China, in December 2019. It is a kind of exceptionally pathogenic human coronavirus (HCoV) whichcauses zoonotic sicknesses and represents a significant risk to general wellbeing. Recognizing thehidden biology and pathogenesis of this novel coronavirus is extremely critical to comprehend as wellas boosting the treatment of this deadly pandemic. The point of this study is to recognize key geneswhich show significant expression in the SARS-CoV-2 infected lungs as compared to healthy ones. Ouranalysis uncovered 149 gene-signatures that show substantial up-regulation in COVID-19 lungs. Outof these, top ten dysregulated genes STAP1, CASP5, FDCSP, CARD17, ST20, AKR1B10, CLC, KCNJ2-AS1,RNASE2 and FLG are found to be significant based on various crucial statistical factors and may endup being acceptable helpful drug targets.

2020

Gene signatures, SARS-CoV-2, COVID-19

DOI: 10.22207/JPAM.14.SPL1.47

Journal of Pure and Applied Microbiology

Journal of Pure and Applied Microbiology

Microbiology