Sensitive detection of SARS-CoV-2 seroconversion by flow cytometry reveals the presence of nucleoprotein-reactive antibodies in unexposed individuals
Título
Sensitive detection of SARS-CoV-2 seroconversion by flow cytometry reveals the presence of nucleoprotein-reactive antibodies in unexposed individuals
Autor
Leire Egia-Mendikute, Alexandre Bosch, Endika Prieto-Fernández, So Young Lee, Borja Jiménez-Lasheras, Ana García del Río, Asier Antoñana-Vildosola, Chiara Bruzzone, Maider Bizkarguenaga, Nieves Embade, Rubén Gil-Redondo, María Luz Martínez-Chantar, Marcos López-Hoyos, Nicola G. A. Abrescia, José M. Mato, Óscar Millet, Asís Palazón
Descripción
Egia-Mendikute et al. develop a multiplexed flow cytometric bead array to simultaneously detect antibodies reactive to three immunogenic SARS-CoV-2 proteins. More sensitive than ELISA, they detected N-reactive antibodies in COVID-19-negative individuals with this assay, showing it to have superior potential to detect low antibody titres compared to current gold standard serology methods.
Fecha
2021
Identificador
10.1038/s42003-021-02011-6
Fuente
Epidemiology and Health
Editor
Korean Society of Epidemiology
Cobertura
Biology (General)
Archivos
Colección
Citación
Leire Egia-Mendikute, Alexandre Bosch, Endika Prieto-Fernández, So Young Lee, Borja Jiménez-Lasheras, Ana García del Río, Asier Antoñana-Vildosola, Chiara Bruzzone, Maider Bizkarguenaga, Nieves Embade, Rubén Gil-Redondo, María Luz Martínez-Chantar, Marcos López-Hoyos, Nicola G. A. Abrescia, José M. Mato, Óscar Millet, Asís Palazón, “Sensitive detection of SARS-CoV-2 seroconversion by flow cytometry reveals the presence of nucleoprotein-reactive antibodies in unexposed individuals,” SOCICT Open, consulta 11 de junio de 2026, http://socictopen.socict.org/items/show/9132.
Position: 17224 (20 views)