New Metrics for Evaluating Viral Respiratory Pathogenesis.

New Metrics for Evaluating Viral Respiratory Pathogenesis.

Vineet D. Menachery, Lisa E Gralinski, Ralph S. Baric, Martin T. Ferris

Viral pathogenesis studies in mice have relied on markers of severe systemic disease, rather than clinically relevant measures, to evaluate respiratory virus infection; thus confounding connections to human disease. Here, whole-body plethysmography was used to directly measure changes in pulmonary function during two respiratory viral infections. This methodology closely tracked with traditional pathogenesis metrics, distinguished both virus- and dose-specific responses, and identified long-term respiratory changes following both SARS-CoV and Influenza A Virus infection. Together, the work highlights the utility of examining respiratory function following infection in order to fully understand viral pathogenesis.

2015

DOI: 10.1371/journal.pone.0131451

PLoS ONE

Public Library of Science (PLoS)

Science, Medicine

EN